Impermanence. Anicca is realized in meditation, not through blind belief. One sees that everything that arises also ceases to be.
One who has seen anicca is no longer attached to people or things. Unattached, true compassion remains.
Anicca is one of the Three Foundations of Existence, sometimes referred to as the Three Characteristics of Existence. Wisdom arises when a meditator realizes all three of the Three Foundations of Existence, the other two being dukkha and anatta.
However, one can see the Three Foundations without seeing dependent origination. Wisdom is thus short of Buddhahood.